Peyronie’s disease is a condition that significantly affects men’s sexual quality of life. It manifests as a curvature of the penis during an erection, often accompanied by pain, caused by the formation of fibrous plaques within the tunica albuginea. This scar tissue prevents the uniform expansion of the penis, resulting in both physical and psychological discomfort. In this comprehensive guide on “Peyronie’s Disease Treatment in London, UK,” we will clearly and accessibly explain the available treatments in London, identify the leading specialists, and show why an innovative and personalized approach such as that of Prof. Fabio Castiglione – one of Europe’s top experts in treating this condition – is the best choice.
Peyronie’s Disease treatment in London, UK: Updated 2025 Guide! What is Peyronie’s Disease?
The disease is named after the French surgeon François de la Peyronie. Although it is a benign condition, it can lead to severe complications, such as:
- Penile curvature (in any direction),
- Pain during erections,
- Shortening of the penis,
- Difficulty during sexual intercourse,
- Erectile dysfunction.
The condition evolves in two phases:
- Active or inflammatory phase (6-18 months): pain, worsening curvature, and plaque activity.
- Chronic or stable phase: the curvature stabilizes, pain may subside, but the fibrosis becomes established.
When to intervene in Peyronie’s Disease Treatment in London, UK
One of the most frequently asked questions by patients is:
- “Should I wait for it to resolve on its own?”
The answer is no: Peyronie’s disease rarely resolves spontaneously. Intervening early increases the effectiveness of non-invasive therapies, prevents the worsening of curvature, and reduces the risk of irreversible erectile dysfunction.
What is the best treatment for Peyronie’s Disease in London in 2025?
Prof. Fabio Castiglione employs a multimodal and personalized approach, based on the stage of the disease and the patient’s clinical response. His exclusive method, known as the P-Shocks Protocol, is now one of the most effective solutions in Europe.
The P-Shocks® Protocol: PRP + Shockwave + Vacuum therapy
This is a regenerative therapy that combines:
- PRP (platelet-rich plasma): Stimulates cellular regeneration and reduces the fibrous plaque.
- Low-intensity Shockwave Therapy (LI-ESWT): Improves blood flow and enhances the flexibility of the penile tissue.
- Vacuum Pump: Promotes tissue elongation and physiological remodeling.
The treatment is:
- Non-invasive,
- Personalized,
- Effective even for patients who do not wish or are unable to undergo surgery.
Prof. Castiglione is one of the few specialists in Europe who has perfected and successfully applied this protocol on hundreds of patients.
Other Non-Surgical treatments available in London
- Intralesional Injections of Verapamil or Collagenase (Xiaflex®): Useful in the early stages of the disease to reduce the plaque.
- Penile Traction Therapy (Penimaster or Phallosan): Beneficial during the active phase to prevent penile shortening.
- Hormonal or Integrative Therapies: Less effective on their own, but sometimes used in combination to improve overall outcomes.
Important: Xiaflex was withdrawn from the European market in 2020, although some specialists continue to offer it through controlled importation.
Surgical interventions for Peyronie’s disease in London
When the curvature is severe and stable, or when it is associated with severe erectile dysfunction, surgical treatment may be the ideal choice.
The options include:
- Nesbit Technique (plicature): Shortens the longer side of the penis to straighten it. Indicated for curvatures less than 60°.
- Plaque Incision with Grafting: A more complex technique that removes part of the plaque and replaces it with a graft. Suitable for more pronounced curvatures.
- Penile Prosthesis: Addresses both curvature and erectile dysfunction in the most complex cases. It is a definitive solution.
Prof. Castiglione only performs the safest and most modern techniques, in collaboration with the best private surgical centers in London.
Looking for the Best Treatment for Peyronie’s Disease Treatment in London, UK? Prof. Castiglione awaits you. Book your appointment at +447830398165!
What Are the Costs for Treating Peyronie’s Disease in London?
Treatment may be free through the NHS, but with very long waiting times and limited options. Patients desiring quick access to innovative solutions often choose the private route.
Indicative estimates (in private practice):
- Initial Consultation: £250 – £400
- Shockwave + PRP (package): £1500 – £3000
- Xiaflex Injection: £2500 per dose (up to 4 doses)
- Surgery: £7000 – £15000
Contact Prof. Castiglione’s office directly at +447830398165 for a personalized plan with transparent costs.
When to consult Prof. Fabio Castiglione in London
Seek a specialist immediately if:
- You notice a progressive curvature of the penis,
- You experience pain during an erection,
- You have sexual difficulties related to the rigidity or shape of the penis,
- You want to avoid surgery and opt for innovative therapies.
Why choose Prof. Fabio Castiglione for Peyronie’s disease treatment in London, UK?
- Internationally renowned urologist and andrologist, with documented clinical and surgical experience at King’s College Hospital.
- Creator of the P-Shocks® Protocol, now adopted by other centers in Europe.
- Specialist in regenerative medicine, with a non-invasive and personalized approach.
- Author of numerous scientific publications on the subject.
- Clinic in the heart of London, easily accessible with immediate consultation.
FAQ – frequently asked questions about Peyronie’s disease
How much does surgery for Peyronie’s cost in the UK?
Private costs vary from £7000 to over £15000, depending on the technique and facility.
What Is the best treatment available today in London?
The P-Shocks® Protocol is among the most innovative and non-invasive solutions, effective in both the active and chronic phases.
Is It possible to Treat Peyronie’s Through the NHS?
Yes, but only some facilities offer limited options with variable waiting times. Regenerative treatments are not available through the NHS.
Is Xiaflex still available in the UK?
Xiaflex was withdrawn from the European market in 2020, but it may still be used in certain cases under specialist supervision.
Can i avoid surgery?
Yes, if intervention is taken early, many patients can resolve the condition with non-surgical treatments such as PRP and shockwave therapy.
Conclusions
The treatment of Peyronie’s Disease in London, UK, has made significant strides in recent years. Today, early and effective intervention is possible thanks to innovative and personalized therapies. Prof. Fabio Castiglione is a European benchmark in regenerative andrological medicine, offering patients tailored therapeutic pathways with concrete and measurable results. Don’t wait for the condition to worsen. Book your specialist consultation with Prof. Fabio Castiglione today.